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Archives of Clinical Neuropsychology Advance Access originally published online on July 31, 2009
Archives of Clinical Neuropsychology 2009 24(6):547-554; doi:10.1093/arclin/acp046
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© The Author 2009. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org.

Relationship of Prospective Memory to Neuropsychological Function and Antiretroviral Adherence

Christopher Contardoa,*, Anne C. Blackb,c, John Beauvaisb,c, Kevin Dieckhausd and Marc I. Rosenb,c

a VA Boston Healthcare System, Neuropsychology Service, Boston, MA, USA
b VA Connecticut Healthcare System, West Haven, CT, USA
c Yale University School of Medicine, New Haven, CT, USA
d University of Connecticut, Health Center, Farmington, CT, USA

* Corresponding author at: VA Boston Healthcare System, 150 South Huntington Ave, Boston, MA 02132, USA. Tel. +1-857-364-6204. E-mail address: chriscontardo{at}gmail.com (C. Contardo).


  Abstract

Prospective memory is defined as the ability to "remember to remember" something at a future time despite intervening distractions and may be particularly important in remembering to take prescribed medication among people infected with HIV. Ninety-seven HIV-positive participants in a clinical trial had their adherence measured by electronic pillcaps and were administered neuropsychological screening tests and the memory for intentions screening test (MIST). Factor analysis of the MIST and other neuropsychological measures identified four factors. Two were derived from MIST subscales and accounted for approximately 50% of the variance in cognitive functioning. Only one factor was significantly correlated with adherence, and this was a MIST factor. In this preliminary study, the MIST assessed a memory function that (a) could be distinguished from traditional retrospective recall and executive functioning and (b) was correlated with antiretroviral adherence.

Keywords HIV; Neuropsychological function; Adherence; Medication compliance; Substance use

Accepted: July 1, 2009


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