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Archives of Clinical Neuropsychology Advance Access originally published online on August 6, 2009
Archives of Clinical Neuropsychology 2009 24(6):599-606; doi:10.1093/arclin/acp047
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© The Author 2009. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org.

Executive Functioning in Twins with Bipolar I Disorder and Healthy Co-Twins

Susanna Juseliusa,b,*, Tuula Kieseppäa,b, Jaakko Kaprioa,c, Jouko Lönnqvista and Annamari Tuulio-Henrikssona,d

a Department of Mental Health and Substance Abuse Services, National Institute for Health and Welfare, Helsinki, Finland
b Department of Psychiatry, Helsinki University Central Hospital, Helsinki, Finland
c Department of Public Health, University of Helsinki, Helsinki, Finland
d Department of Psychology, University of Helsinki, Helsinki, Finland

* Corresponding author at: Department of Psychiatry, Helsinki University Central Hospital, PO Box 813, 00029 Helsinki, Finland. Tel.: +358-98164561; fax: +358-98133418. E-mail address: susanna.r.juselius{at}hus.fi (S. Juselius).


  Abstract

The aims of the study were to compare performance of twins with bipolar disorder (BPD) and healthy co-twins in neuropsychological tests assessing various aspects of executive functioning and to examine the relationship of clinical factors with executive functions. Twenty-six euthymic BPD twins, 19 co-twins, and 114 control twins were examined using the Stroop test, the Wisconsin card sorting test (WCST), the trail making test (TMT), and semantic and phonemic verbal fluency tests. BPD twins and co-twins performed worse than controls in the Stroop test. BPD twins scored lower than controls in semantic fluency. Clinical factors correlated with scores in TMT, WCST, and semantic fluency. Our results suggest that the response inhibition impairment may associate with genetic risk of BPD and represent a potential endophenotype for BPD. The impaired performance in the semantic fluency test among the patients may result from semantic memory retrieval problems.

Keywords Bipolar disorder; Twins; Executive functions; Response inhibition

Accepted: July 13, 2009


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